7-Iodoimidazo[5,1-B]thiazole → HCID 22390245, compound

HRID 1072346Notes

Reaction equation

HRID 1072346 reaction equation
I[C:2]1[N:3]=[CH:4][N:5]2[CH:9]=[CH:8][S:7][C:6]=12.[N:10]([CH2:13][CH2:14][S:15][C:16]1[CH:17]=[N:18][CH:19]=[C:20]([CH:22]=[O:23])[CH:21]=1)=[N+:11]=[N-:12]>>[N:10]([CH2:13][CH2:14][S:15][C:16]1[CH:21]=[C:20]([C:22]([C:2]2[N:3]=[CH:4][N:5]3[CH:9]=[CH:8][S:7][C:6]=23)=[O:23])[CH:19]=[N:18][CH:17]=1)=[N+:11]=[N-:12]

Participants

3

Reactant 2

HCID 177737777-Iodoimidazo[5,1-B]thiazoleHCID 22390293HCID 22390293, compound

Product 1

HCID 22390245HCID 22390245, compoundYield 73.8%

Procedure

7-[5-(2-Azidoethylthio)pyridin-3-yl]carbonylimidazo[5,1-b]thiazole (667 mg) was prepared in the same manner as in step a) of Synthesis Example 3, except that 650 g of 7-iodoimidazo[5,1-b]thiazole and 570 mg of 3-(2-azidoethylthio)pyridine-5-aldehyde were used as the starting compounds.

Workup

  1. customof Synthesis Example 3

Sources & evidence

ORD record
ord-f18b018cda394a83b7a2594f10e73b4a
Source dataset
uspto-grants-2005_06
Patent number
US06908913B2

Reaction notes

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