HCID 131725008, compound → HCID 69366131, compound

Participants

Reaction Steps

A reaction was carried out in the same manner as in step b) of Example 1, except that 450 mg of 4-nitrobenzyl (1S,5R,6S)-2-[7-[1-(3-azidopropyl)pyridinium-3-yl]carbonylimidazo[5,1-b]thiazol-2-yl]-6-((1R)-1-hydroxyethyl)-1-methyl-1-carbapen-2-em-3-carboxylate trifluoromethanesulfonate was used as the starting compound. The reaction product was subjected to column chromatography on Cosmosil 40C18-PREP (10% aqueous methanol solution). The fraction, which had been eluted earlier, was collected and was then ion exchanged by column chromatography (water) on Amberlyst (A-26) to give 38 mg of the title compound.

Provenance & Evidence