Methyl triflate → 4-Nitrobenzyl (1s,5r,6s)-6-((1r)-1-hydroxyethyl)-1-methyl-2-[7-(1-methylpyridinium-3-yl)carbonylimidazo-[5,1-b]thiazol-2-yl]-1-carbapen-2-em-3-carboxylate trifluoromethanesulfonate

Participants

Reaction Steps

4-Nitrobenzyl (1S,5R,6S)-6-((1R)-1-hydroxyethyl)-1-methyl-2-[7-(pyridin-3-yl)carbonylimidazo[5,1-b]thiazol-2-yl]-1-carbapen-2-em-3-carboxylate (240 mg) was suspended in 10 ml of dichloromethane to prepare a suspension. Methyl trifluoromethanesulfonate (0.047 ml) was added to the suspension, and the mixture was stirred at room temperature for 20 min. The reaction solution was concentrated under the reduced pressure to give 333 mg of 4-nitrobenzyl (1S,5R,6S)-6-((1R)-1-hydroxyethyl)-1-methyl-2-[7-(1-methylpyridinium-3-yl)carbonylimidazo-[5,1-b]thiazol-2-yl]-1-carbapen-2-em-3-carboxylate trifluoromethanesulfonate.

Provenance & Evidence