HRID1072366

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[C@@H](O)[C@H]1C(=O)N2[C@@H](C(=O)OCc3ccc([N+](=O)[O-])cc3)C(=O)[C@H](C)[C@H]12

HCID13504349

未命名化合物

结构：CCC[CH2][Sn]([CH2]CCC)([CH2]CCC)[c]1cn2cnc(C(=O)c3cncc(SC)c3)c2s1

HCID22390228

未命名化合物

PRODUCTS

生成物

结构：CSc1cncc(C(=O)c2ncn3cc(C4=C(C(=O)OCc5ccc([N+](=O)[O-])cc5)N5C(=O)[C@H]([C@@H](C)O)[C@H]5[C@H]4C)sc23)c1

HCID91100986

未命名化合物

收率 50.9%

PROCEDURE

实验过程

4-Nitrobenzyl (1S,5R,6S)-6-((1R)-1-hydroxyethyl)-1-methyl-2-[7-(5-methylthiopyridin-3-yl)carbonylimidazo[5,1-b]thiazol-2-yl]-1-carbapen-2-em-3-carboxylate (100 mg) was prepared in substantially the same manner as in step a) of Example 1, except that 169 mg of 4-nitrobenzyl (1R,3R,5R,6S)-6-((1R)-1-hydroxyethyl)-1-methyl-2-oxo-1-carbapenam-3-carboxylate and 179 mg of 7-(5-methylthiopyridin-3-yl)carbonyl-2-(tri-n-butylstannyl)imidazo[5,1-b]thiazole were used as the starting compounds.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-13713471f7a84f9dbb56e8e5b102206f
来源数据集: uspto-grants-2005_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06908913B2
来源说明: uspto-grants-2005_06

反应 SMILES

[OH:1][C@@H:2]([C@H:4]1[C:25](=[O:26])[N:6]2[C@@H:7]([C:12]([O:14][CH2:15][C:16]3[CH:21]=[CH:20][C:19]([N+:22]([O-:24])=[O:23])=[CH:18][CH:17]=3)=[O:13])[C:8](=O)[C@H:9]([CH3:10])[C@H:5]12)[CH3:3].[CH3:27][S:28][C:29]1[CH:30]=[C:31]([C:35]([C:37]2[N:38]=[CH:39][N:40]3[CH:44]=[C:43]([Sn](CCCC)(CCCC)CCCC)[S:42][C:41]=23)=[O:36])[CH:32]=[N:33][CH:34]=1>>[OH:1][C@@H:2]([C@H:4]1[C:25](=[O:26])[N:6]2[C:7]([C:12]([O:14][CH2:15][C:16]3[CH:21]=[CH:20][C:19]([N+:22]([O-:24])=[O:23])=[CH:18][CH:17]=3)=[O:13])=[C:8]([C:43]3[S:42][C:41]4=[C:37]([C:35]([C:31]5[CH:32]=[N:33][CH:34]=[C:29]([S:28][CH3:27])[CH:30]=5)=[O:36])[N:38]=[CH:39][N:40]4[CH:44]=3)[C@H:9]([CH3:10])[C@H:5]12)[CH3:3]