Iodoacetamide → 4-Nitrobenzyl (1s,5r,6s)-2-[7-[5-(2-azidoethylthio)-1-carbamoylmethylpyridinium-3-yl]carbonylimidazo[5,1-b]thiazol-2-yl]-6-((1r)-1-hydroxyethyl)-1-methyl-1-carbapen-2-em-3-carboxylate iodide

Participants

Reaction Steps

4-Nitrobenzyl (1S,5R,6S)-2-[7-[5-(2-azidoethylthio)-1-carbamoylmethylpyridinium-3-yl]carbonylimidazo[5,1-b]thiazol-2-yl]-6-((1R)-1-hydroxyethyl)-1-methyl-1-carbapen-2-em-3-carboxylate iodide (140 mg) was prepared in the same manner as in step a) of Example 2, except that 114 mg of 4-nitrobenzyl (1S,5R,6S)-2-[7-[5-(2-azidoethylthio)pyridin-3-yl]carbonylimidazo[5,1-b]-thiazol-2-yl]-6-((1R)-1-hydroxyethyl)-1-methyl-1-carbapen-2-em-3-carboxylate and 312 mg of 2-iodoacetamide were used as the starting compounds.

Provenance & Evidence