Hydrochloric Acid → HCID 69362846, compound

Participants

Reaction Steps

The crude product (398 mg) of 4-nitrobenzyl (1S,5R,6S)-2-[7-[1-((2R)-3-azido-2-triethylsilyloxypropyl)pyridinium-3-yl]carbonylimidazo[5,1-b]thiazol-2-yl]-6-((1R)-1-hydroxyethyl)-1-methyl-1-carbapen-2-em-3-carboxylate trifluoromethanesulfonate was dissolved in 12 ml of THF and 12 ml of water to prepare a solution. The solution was adjusted to pH 2.2 by the addition of 1 N hydrochloric acid and was stirred for 24 hr. The solution was adjusted to pH 5 by the addition of a 5% aqueous sodium hydrogencarbonate solution, and a reaction was then carried out in the same manner as in step b) of Example 4. Thus, 56 mg of the title compound was prepared.

Provenance & Evidence