HCID 22390272, compound → HCID 69363803, compound

HRID 1072394Notes

Reaction equation

HRID 1072394 reaction equation
[Cl:1][C:2]1[N:9]2[C:5]([S:6][C:7]([C:10]3[C@H:11]([CH3:34])[C@@H:12]4[C@@H:29]([C@H:30]([OH:32])[CH3:31])[C:28](=[O:33])[N:13]4[C:14]=3[C:15]([O:17]CC3C=CC([N+]([O-])=O)=CC=3)=[O:16])=[CH:8]2)=[C:4]([C:35]([C:37]2[CH:38]=[N:39][CH:40]=[CH:41][CH:42]=2)=[O:36])[N:3]=1.[N+](C1C=CC(COC([NH:54][S:55]([NH:58][CH2:59][CH2:60][CH2:61]O)(=[O:57])=[O:56])=O)=CC=1)([O-])=O>>[Cl:1][C:2]1[N:9]2[C:5]([S:6][C:7]([C:10]3[C@H:11]([CH3:34])[C@@H:12]4[C@@H:29]([C@H:30]([OH:32])[CH3:31])[C:28](=[O:33])[N:13]4[C:14]=3[C:15]([O-:17])=[O:16])=[CH:8]2)=[C:4]([C:35]([C:37]2[CH:38]=[N+:39]([CH2:61][CH2:60][CH2:59][NH:58][S:55](=[O:57])(=[O:56])[NH2:54])[CH:40]=[CH:41][CH:42]=2)=[O:36])[N:3]=1

Participants

3

Reactant 2

HCID 22390272HCID 22390272, compoundHCID 91423358HCID 91423358, compound

Product 1

HCID 69363803HCID 69363803, compoundYield 29.3%

Procedure

The title compound (64 mg) was prepared in the same manner as in steps a) and b) of Example 4, except that 218 mg of 4-nitrobenzyl (1S,5R,6S)-2-[5-chloro-7-(pyridin-3-yl)carbonylimidazo[5,1-b]thiazol-2-yl]-6-((1R)-1-hydroxyethyl)-1-methyl-1-carbapen-2-em-3-carboxylate and 160 mg of 3-(4-nitrobenzyloxycarbonylaminosulfonyl)aminopropanol were used as the starting compounds.

Sources & evidence

ORD record
ord-bb28da8a22814c66a9e442af47916582
Source dataset
uspto-grants-2005_06
Patent number
US06908913B2

Reaction notes

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