HRID1072396

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(NS(=O)(=O)NCCO)OCc1ccc([N+](=O)[O-])cc1

HCID22390400

未命名化合物

结构：C[C@@H](O)[C@H]1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=C(c3cn4cnc(C(=O)c5cccnc5)c4s3)[C@H](C)[C@H]12

HCID68934911

未命名化合物

PRODUCTS

生成物

结构：C[C@@H](O)[C@H]1C(=O)N2C(C(=O)[O-])=C(c3cn4cnc(C(=O)c5ccc[n+](CCNS(N)(=O)=O)c5)c4s3)[C@H](C)[C@H]12

HCID10144305

未命名化合物

收率 17.7%

PROCEDURE

实验过程

The title compound (101 mg) was prepared in the same manner as in steps a) and b) of Example 4, except that 572 mg of 2-(4-nitrobenzyloxycarbonylaminosulfonyl)aminoethanol was used instead of 3-azido-1-propanol in step a) of Example 4 and 585 mg of 4-nitrobenzyl (1S,5R,6S)-6-((1R)-1-hydroxyethyl)-1-methyl-2-[7-(pyridin-3-yl)carbonylimidazo[5,1-b]thiazol-2-yl]-1-carbapen-2-em-3-carboxylate was used as the starting compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-695c5ddf3fbe443c9a8555c3b035c538
来源数据集: uspto-grants-2005_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06908913B2
来源说明: uspto-grants-2005_06

反应 SMILES

[N+](C1C=CC(COC([NH:12][S:13]([NH:16][CH2:17][CH2:18]O)(=[O:15])=[O:14])=O)=CC=1)([O-])=O.[OH:22][C@@H:23]([C@H:25]1[C:61](=[O:62])[N:27]2[C:28]([C:48]([O:50]CC3C=CC([N+]([O-])=O)=CC=3)=[O:49])=[C:29]([C:32]3[S:36][C:35]4=[C:37]([C:40]([C:42]5[CH:43]=[N:44][CH:45]=[CH:46][CH:47]=5)=[O:41])[N:38]=[CH:39][N:34]4[CH:33]=3)[C@H:30]([CH3:31])[C@H:26]12)[CH3:24]>>[OH:22][C@@H:23]([C@H:25]1[C:61](=[O:62])[N:27]2[C:28]([C:48]([O-:50])=[O:49])=[C:29]([C:32]3[S:36][C:35]4=[C:37]([C:40]([C:42]5[CH:43]=[N+:44]([CH2:18][CH2:17][NH:16][S:13](=[O:15])(=[O:14])[NH2:12])[CH:45]=[CH:46][CH:47]=5)=[O:41])[N:38]=[CH:39][N:34]4[CH:33]=3)[C@H:30]([CH3:31])[C@H:26]12)[CH3:24]