Water → HCID 22386552, compound

Participants

Reaction Steps

A solution of 4-(5-Ethylsulfanyl-imidazo[1,2-c]pyrimidin-7yl)-2-methoxy-benzenesulfonylchloride (200 mg, 0.52 mmol) and piperidine (89 mg, 1.04 mmol) in CH2Cl2: MeOH (2:1, 5 ml). was stirred overnight at room temperature. Water was added to the reaction mixture and extraction was carried out with CH2Cl2. The combined organic layer was washed with brine and dried over Na2SO4. The organic layer was concentrated to give the crude product of 5-Ethylsulfanyl-7-[3-methoxy-4-(piperidine-1-sulfonyl)-phenyl]imidazo[1,2-c]pyrimidine which was purified by preparative thin layer chromatography (45 mg, 20%).

Provenance & Evidence