Water → HCID 22386542, compound

Participants

Reaction Conditions

Reaction Steps

To 4-(5-Ethylsulfanyl-imidazo[1,2-c]pyrimidin-7-yl)-benzene-1,2-diol (86.2 mg, 0.3 mmol) in DMF (2 ml) were added ethyl bromide (112 μl, 1.5 mmol) and K2CO3 (290 mg, 2.1 mmol). The reaction mixture was stirred at about 50° C. overnight. After cooling to room temperature, it was poured into water and extracted with EtOAc. The combined organic extract was dried over MgSO4 and concentrated in vacuo. The residue was purified by preparative thin layer chromatography to give 7-(3,4-Diethoxy-phenyl)-5-ethylsulfanyl-imidazo[1,2-c]pyrimidine (39.1 mg, yield 36%).

Provenance & Evidence