1-(4-Fluorophenyl)piperazine → HCID 22386540, compound

Participants

Reaction Steps

The mixture of 5-chloro-7-(3,4-dimethoxyphenyl) imidazo[1,2-c]pyrimidine (57.94 mg, 0.2 mmol), 1-(4-fluorophenyl)piperazine.2HCl (55.69 mg, 0.22 mmol), and diisopropylethylamine (85.31 mg, 0.66 mmol) in 3 ml of 2-propanol was stirred at 90° C. for 3 h, and cooled to room temperature. To the obtained mixture, 3 ml of ice water was added, the produced white solid was collected by filtration, and dried to give the pure product (56 mg, 64.6%) of 7-(3,4-Dimethoxyphenyl)-5-[4-(4-fluorophenyl)piperazin-1-yl]-imidazo[-1,2-c]pyrimidine.

Provenance & Evidence