反应详情

This compound was prepared in similar manner as for Intermediate 17, using 4-(5-Fluoro-1-H-indol-3-yl)-cyclohexanone (0.6 g, 2.6 mmol) and benzylamine (0.3 g, 2.8 mmol) to afford 1.0 of the desired product as a mixture of cis and trans isomers. Flash chromatography on silica gel (3% 2M NH3 in methanol/ethyl acetate) afforded 0.41 g (65%) of cis isomer and 0.22 g (33%) of the trans isomer.