反应详情

A mixture of intermediate (2) (0.066 mole) in CH3OH (200 ml) was hydrogenated at RT under a 3 bar pressure for 1 hour with Raney Nickel (15 g) as a catalyst. After uptake of H2, the catalyst was filtered through celite, washed with CH3OH and the filtrate was evaporated, yielding 17.1 g of 4-amino-2,6-dichloro-α,α-dimethylbenzeneacetonitrile (intermediate 3).

1. filtrationAfter uptake of H2, the catalyst was filtered through celite
2. washwashed with CH3OH
3. customthe filtrate was evaporated