HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1072502Generated: October 26, 2026
1-[(3,4-Dichlorophenyl)methyl]piperidin-4-amine → N-(2-{3-[1-(3,4-Dichloro-benzyl)-piperidin-4-ylamino]-2-hydroxy-propoxy}-phenyl)-benzamide
https://huagongshe.com/reaction/1072502
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-[(3,4-Dichlorophenyl)methyl]piperidin-4-amine | HCID 10978156 | — |
| Reactant | N-(2-Oxiranylmethoxy-phenyl)-benzamide | HCID 22386962 | — |
| Product | N-(2-{3-[1-(3,4-Dichloro-benzyl)-piperidin-4-ylamino]-2-hydroxy-propoxy}-phenyl)-benzamide | HCID 10119159 | — |
Reaction Steps
To a solution of N-(2-Oxiranylmethoxy-phenyl)-benzamide (0.2 ml, 0.1M in DMSO) was added (0.2 ml, 0.1M in EtOH) of 1-(3,4-Dichloro-benzyl)-piperidin-4-ylamine. The resulting mixture was heated at 75-80° C. for 24 hours. The ethanol was removed and the product was purified with preparative LC/MS.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06911458B2 |
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| Source dataset | uspto-grants-2005_06 |
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| ORD ID | ord-e2eb10ff0d72400caa470575bba00bdd |
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| Source note | uspto-grants-2005_06 |
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