反应详情

At 0° C., 1 mmol of 6,8-dichloro-2-methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinoline (intermediate 4, example 2) was introduced into 1 ml of chlorosulfonic acid and stirred at room temperature for 3 hours. For workup, the reaction mixture was poured onto ice, adjusted to pH 7 to 8 with 1 N NaOH and extracted twice with ethyl acetate. The combined ethyl acetate phases were dried with Na2SO4 and concentrated in a rotary evaporator. The crude product obtained in this way was reacted further without further purification.

1. additionFor workup, the reaction mixture was poured onto ice
2. extractionextracted twice with ethyl acetate
3. dry with materialThe combined ethyl acetate phases were dried with Na2SO4
4. concentrationconcentrated in a rotary evaporator