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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1072506Generated: October 26, 2026

Sodium borohydride → 2-((2,4-Dichlorobenzyl)(methyl)amino)-1-(4-bromophenyl)ethanol

https://huagongshe.com/reaction/1072506

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium borohydrideHCID 4311764—
Reactant6,8-Dichloro-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolineHCID 22386807—
Reactant1-(4-Bromophenyl)-2-((2,4-dichlorobenzyl)(methyl)amino)ethanoneHCID 22386828—
Product2-((2,4-Dichlorobenzyl)(methyl)amino)-1-(4-bromophenyl)ethanolHCID 2238684886%

Reaction Steps

Intermediate 1 was reduced to the corresponding alcohol with 2 equivalents of NaBH4 in analogy to the manner described for intermediate 4, example 1, and the alcohol was isolated in a yield of 86%.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06911453B2
Source datasetuspto-grants-2005_06
ORD IDord-4c629c70208d4be086b4f057553e5590
Source noteuspto-grants-2005_06