Methyl isothiocyanate → HCID 10293135, compound

HRID 1072514Notes

Reaction equation

HRID 1072514 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([Cl:12])[CH:11]=1)[CH2:8][N:7]([CH3:13])[CH2:6][CH:5]2[C:14]1[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][CH:15]=1.[CH3:21][N:22]=[C:23]=[S:24].NC(N)=S>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([Cl:12])[CH:11]=1)[CH2:8][N:7]([CH3:13])[CH2:6][CH:5]2[C:14]1[CH:19]=[CH:18][C:17]([NH:20][C:23]([NH:22][CH3:21])=[S:24])=[CH:16][CH:15]=1

Participants

4

Reactant 3

HCID 11167Methyl isothiocyanateHCID 2723790ThioureaHCID 99443944-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)aniline

Product 1

HCID 10293135HCID 10293135, compound

Procedure

Proceeding in analogy to the method described in example 19 and starting from 500 mg (1.63 mmol) of 4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-yl)-phenylamine (see example 17) and 220 mg (3.0 mmol) of methyl isothiocyanate allowed 245 mg of the desired thiourea to be isolated.

Workup

  1. customto be isolated

Sources & evidence

ORD record
ord-db092ae560b44f00a768389d1397fc4f
Source dataset
uspto-grants-2005_06
Patent number
US06911453B2

Reaction notes

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