Cyclopropanemethanamine → HCID 131725014, compound

HRID 1072516Notes

Reaction equation

HRID 1072516 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([Cl:12])[CH:11]=1)[CH2:8][N:7]([CH3:13])[CH2:6][CH:5]2[C:14]1[CH:19]=[CH:18][C:17]([NH:20][C:21](=[O:23])[CH3:22])=[CH:16][CH:15]=1.[CH:24]1([CH2:27][NH2:28])[CH2:26][CH2:25]1>>[ClH:12].[Cl:12][C:10]1[CH:11]=[C:2]([NH:28][CH2:27][CH:24]2[CH2:26][CH2:25]2)[CH:3]=[C:4]2[C:9]=1[CH2:8][N:7]([CH3:13])[CH2:6][CH:5]2[C:14]1[CH:19]=[CH:18][C:17]([NH:20][C:21](=[O:23])[CH3:22])=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 75646CyclopropanemethanamineHCID 10293999HCID 10293999, compound

Product 1

HCID 131725014HCID 131725014, compound

Procedure

Preparation takes place in analogy to the method described in example 25, starting from N-[4-(6-bromo-8-chloro-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-yl)-phenyl]-acetamide (example 24) and C-cyclopropyl-methylamine. The chromatography on silica gel was followed by a further purification on a preparative HPLC. The purified compound was dissolved in 1 N HCl, diluted with H2O and freeze dried.

Workup

  1. customPreparation
  2. customThe chromatography on silica gel was followed by a further purification on a preparative HPLC
  3. dissolutionThe purified compound was dissolved in 1 N HCl
  4. additiondiluted with H2O and freeze
  5. customdried

Sources & evidence

ORD record
ord-2dded38142bb44babcc912d2cf3d1a27
Source dataset
uspto-grants-2005_06
Patent number
US06911453B2

Reaction notes

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