Methanesulfonyl chloride → N-[4-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-yl)-phenyl]-methanesulfonamide, Hydrochloride

HRID 1072523Notes

Reaction equation

HRID 1072523 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([Cl:12])[CH:11]=1)[CH2:8][N:7]([CH3:13])[CH2:6][CH:5]2[C:14]1[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][CH:15]=1.[CH3:21][S:22](C1C=CC(CNC)=CC=1)(=[O:24])=[O:23].CS(Cl)(=O)=O>>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([Cl:12])[CH:11]=1)[CH2:8][N:7]([CH3:13])[CH2:6][CH:5]2[C:14]1[CH:19]=[CH:18][C:17]([NH:20][S:22]([CH3:21])(=[O:24])=[O:23])=[CH:16][CH:15]=1

Participants

4

Reactant 3

HCID 31297Methanesulfonyl chlorideHCID 99443944-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)anilineHCID 22386825[(4-Methanesulfonylphenyl)methyl](methyl)amine

Product 1

HCID 131725017N-[4-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-yl)-phenyl]-methanesulfonamide, Hydrochloride

Procedure

The process is analogous to the method described in example 82, starting from the compound of example 17, intermediate 1, and methanesulfonyl chloride.

Sources & evidence

ORD record
ord-f647b3dd96a94aca922452a75c78b139
Source dataset
uspto-grants-2005_06
Patent number
US06911453B2

Reaction notes

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