Cyclohexanecarbonyl chloride → Benzimidazole

HRID 1072535Notes

Reaction equation

NC1C=CC([C:8]2[NH:9][C:10]3[CH:16]=[CH:15][C:14](N)=[CH:13][C:11]=3[N:12]=2)=CC=1.C1(C(Cl)=O)CCCCC1>>[N:9]1[C:10]2[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=2[NH:12][CH:8]=1

Participants

Reactant 2

HCID 75938Cyclohexanecarbonyl chloride

HCID 178507432HCID 178507432, compound

Product 1

HCID 5798Benzimidazole

Procedure

2-(N-Cyclohexylcarbonyl-4′-aminophenyl)-6-cyclohexylcarbonylamino)-benzimidazole was prepared by Method A from 2-(4-aminophenyl)-6-aminobenzimidazole (0.195 g, 0.87 mmole) and cyclohexylcarbonyl chloride (0.291 ml, 0.319 g, 2.175 mmole). The resulting solid (76.7 mg) was purified by preparative HPLC.

Workup

customThe resulting solid (76.7 mg) was purified by preparative HPLC

Sources & evidence

ORD record: ord-846edf29646848ffb9b26b83d99d7e9d
Source dataset: uspto-grants-2005_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06911462B2

Reaction notes

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