Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | Rac-(1r,4r)-4-methoxycyclohexane-1-carboxylic acid | HCID 736153 | — |
| Reactant | HCID 178507432 | HCID 178507432 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Carbonyl benzimidazole | HCID 22387228 | — |
Reaction Steps
Bis-4-methoxyclohexyl carbonyl benzimidazole was synthesized as follows: Oxalyl chloride, (1.07. ml, 2 M in CH2Cl2) was added to 4-methoxy-cyclohexane carboxylic acid (0.338 g, 2.14 mmole) followed by one drop DMF. The mixture was allowed to react at RT for 1.0 hour. To the above solution was added 2-(4-aminophenyl)-6-amino-benzimidazole (0.200 g, 0.89 mmole) in pyridine (2 ml). The reaction was heated to 60° C. overnight. The reaction was cooled and the precipitate filtered and washed with NaHCO3 and hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06911462B2 |
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| Source dataset | uspto-grants-2005_06 |
|---|
| ORD ID | ord-cfd0421849c2497a88f7d19f0c404465 |
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| Source note | uspto-grants-2005_06 |
|---|
