反应详情

To a solution of metformin in dry toluene was slowly added heptafluorobutyric anhydride (1.2 equivalents) and stirred at ambient temperature for 4 hours. The reaction was terminated by addition of water and the reaction mixture was precipitated in acetone. The crude fluorinated metformin was chromatographed on silica gel, yielding N-heptafluorobutyryl N,N′-dimethylimidodicarbonimidic diamide.

1. customThe reaction was terminated by addition of water
2. customthe reaction mixture was precipitated in acetone
3. customwas chromatographed on silica gel