Boron tribromide → HCID 22387344, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-(4-bromophenyl)-5-(4-methoxyphenyl)-2,3-dimethyl-1H-pyrrole (610 mg, 1.71 mmol) in methylene chloride (30 ml) was added boron tribromide (0.647 ml, 6.84 mmol) at 0° C. The obtained solution was stirred at 0° C. for 1 hour, poured into ice water and extracted with ethyl acetate. The extracts were collected and washed with saturated aqueous sodium bicarbonate and dried over magnesium sulfate anhydride, and the solvent was removed under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=6:1) to isolate the object compound as an oily substance. 358 mg (yield: 61.2%)

Provenance & Evidence