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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1072712Generated: November 3, 2026

Sodium Hydroxide → Sodium (2R)-2-(4-{1-[3-(4-Butylphenyl)propan-1-yl]-5-methyl-1H-pyrrol-2-yl}phenoxy)-3-phenylpropanoate

https://huagongshe.com/reaction/1072712

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium HydroxideHCID 14798—
Reactant(2R)-2-(4-{1-[3-(4-butylphenyl)propan-1-yl]-5-methyl-1H-pyrrol-2-yl}phenoxy)-3-phenylpropanoic acidHCID 69732919—
SolventEthanolHCID 702—
ProductSodium (2R)-2-(4-{1-[3-(4-Butylphenyl)propan-1-yl]-5-methyl-1H-pyrrol-2-yl}phenoxy)-3-phenylpropanoateHCID 8658889367%

Reaction Steps

Ethanol (30 ml) and a solution of 1N sodium hydroxide in ethanol (2.74 ml) were added to (2R)-2-(4-{1-[3-(4-butylphenyl)propan-1-yl]-5-methyl-1H-pyrrol-2-yl}phenoxy)-3-phenylpropanoic acid (1.51 g, 3.05 mmol) and the mixture was concentrated. To the residue was added diisopropylether to give the object compound as a solid. 1.06 g (yield 67.0%)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06911468B2
Source datasetuspto-grants-2005_06
ORD IDord-2b45bdcf313a4bd28aad6f28e4202897
Source noteuspto-grants-2005_06