HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → Sodium (2R)-2-(4-{1-[3-(4-Butylphenyl)propan-1-yl]-5-methyl-1H-pyrrol-2-yl}phenoxy)-3-phenylpropanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | (2R)-2-(4-{1-[3-(4-butylphenyl)propan-1-yl]-5-methyl-1H-pyrrol-2-yl}phenoxy)-3-phenylpropanoic acid | HCID 69732919 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Sodium (2R)-2-(4-{1-[3-(4-Butylphenyl)propan-1-yl]-5-methyl-1H-pyrrol-2-yl}phenoxy)-3-phenylpropanoate | HCID 86588893 | 67% |
Reaction Steps
Ethanol (30 ml) and a solution of 1N sodium hydroxide in ethanol (2.74 ml) were added to (2R)-2-(4-{1-[3-(4-butylphenyl)propan-1-yl]-5-methyl-1H-pyrrol-2-yl}phenoxy)-3-phenylpropanoic acid (1.51 g, 3.05 mmol) and the mixture was concentrated. To the residue was added diisopropylether to give the object compound as a solid. 1.06 g (yield 67.0%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06911468B2 |
| Source dataset | uspto-grants-2005_06 |
| ORD ID | ord-2b45bdcf313a4bd28aad6f28e4202897 |
| Source note | uspto-grants-2005_06 |