Sodium Hydroxide → HCID 86759775, compound

HRID 1072734Notes

Reaction equation

HRID 1072734 reaction equation
[OH-].[Na+:2].[CH3:3][C:4]1[N:8]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])=[CH:13][CH:12]=2)[C:7]([C:30]2[CH:47]=[CH:46][C:33]([O:34][C@H:35]([CH2:39][C:40]3[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=3)[C:36]([OH:38])=[O:37])=[CH:32][CH:31]=2)=[CH:6][CH:5]=1>C(O)C>[CH3:3][C:4]1[N:8]([CH2:9][CH2:10][C:11]2[CH:12]=[CH:13][C:14]([O:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])=[CH:15][CH:16]=2)[C:7]([C:30]2[CH:47]=[CH:46][C:33]([O:34][C@H:35]([CH2:39][C:40]3[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=3)[C:36]([O-:38])=[O:37])=[CH:32][CH:31]=2)=[CH:6][CH:5]=1.[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69731973HCID 69731973, compound

Product 1

HCID 86759775HCID 86759775, compoundYield 52.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Ethanol (3 ml) and a solution of 1N sodium hydroxide in ethanol (0.480 ml) were added to (2R)-2-{4-[5-methyl-1-(4-dodecyloxyphenethyl)-1H-pyrrol-2-yl]phenoxy}-3-phenylpropanoic acid (325 mg, 0.533 mmol) and the mixture was concentrated. To the residue was added ether to give the object compound as a solid. 160 mg (yield: 52.8%)

Workup

  1. concentrationthe mixture was concentrated
  2. additionTo the residue was added ether

Sources & evidence

ORD record
ord-4511544aa413468b9d0d16eb3edafaf5
Source dataset
uspto-grants-2005_06
Patent number
US06911468B2

Reaction notes

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