Sodium Hydroxide → HCID 86759776, compound

HRID 1072736Notes

Reaction equation

HRID 1072736 reaction equation
[OH-].[Na+:2].[CH3:3][C:4]1[N:8]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[CH:13][CH:12]=2)[C:7]([C:29]2[CH:46]=[CH:45][C:32]([O:33][C@H:34]([CH2:38][C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=3)[C:35]([OH:37])=[O:36])=[CH:31][CH:30]=2)=[CH:6][CH:5]=1>C(O)C>[CH3:3][C:4]1[N:8]([CH2:9][CH2:10][C:11]2[CH:12]=[CH:13][C:14]([O:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[CH:15][CH:16]=2)[C:7]([C:29]2[CH:46]=[CH:45][C:32]([O:33][C@H:34]([CH2:38][C:39]3[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=3)[C:35]([O-:37])=[O:36])=[CH:31][CH:30]=2)=[CH:6][CH:5]=1.[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69732714HCID 69732714, compound

Product 1

HCID 86759776HCID 86759776, compoundYield 83.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Ethanol (5 ml) and a solution of 1N sodium hydroxide in ethanol (0.724 ml) were added to (2R)-2-{4-[5-methyl-1-(4-undecyloxyphenethyl)-1H-pyrrol-2-yl]phenoxy}-3-phenylpropanoic acid (480 mg, 0.804 mmol) and the mixture was concentrated. To the residue was added hexane to give the object compound as a solid. 375 mg (yield: 83.9%)

Workup

  1. concentrationthe mixture was concentrated
  2. additionTo the residue was added hexane

Sources & evidence

ORD record
ord-f3c5544a047a4c1483c197192814676e
Source dataset
uspto-grants-2005_06
Patent number
US06911468B2

Reaction notes

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