HRID1072751

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

结构：Cc1ccc(-c2ccc(O[C@H](Cc3ccccc3)C(=O)O)cc2)n1CCCOc1ccc(Cc2ccccc2)cc1

HCID69730769

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(-c2ccc(O[C@H](Cc3ccccc3)C(=O)[O-])cc2)n1CCCOc1ccc(Cc2ccccc2)cc1.[Na+]

HCID86759779

未命名化合物

收率 87.3%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

2 次

PROCEDURE

实验过程

Ethanol (5 ml) and a solution of 1N sodium hydroxide in ethanol (0.900 ml) were added to (2R)-2-(4-{1-[3-(4-benzylphenoxy)propyl]-5-methyl-1H-pyrrol-2-yl}phenoxy)-3-phenylpropanoic acid (546 mg, 1.00 mmol) and the mixture was concentrated. To the residue was added diisopropylether to give the object compound as a solid. 447 mg (yield: 87.3%)

WORKUP

后处理

concentrationthe mixture was concentrated
additionTo the residue was added diisopropylether

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-35db451ce3fe4fd0a852dfbf8d916c06
来源数据集: uspto-grants-2005_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06911468B2
来源说明: uspto-grants-2005_06

反应 SMILES

[OH-].[Na+:2].[CH2:3]([C:10]1[CH:43]=[CH:42][C:13]([O:14][CH2:15][CH2:16][CH2:17][N:18]2[C:22]([CH3:23])=[CH:21][CH:20]=[C:19]2[C:24]2[CH:41]=[CH:40][C:27]([O:28][C@H:29]([CH2:33][C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)[C:30]([OH:32])=[O:31])=[CH:26][CH:25]=2)=[CH:12][CH:11]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>C(O)C>[CH2:3]([C:10]1[CH:11]=[CH:12][C:13]([O:14][CH2:15][CH2:16][CH2:17][N:18]2[C:22]([CH3:23])=[CH:21][CH:20]=[C:19]2[C:24]2[CH:25]=[CH:26][C:27]([O:28][C@H:29]([CH2:33][C:34]3[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=3)[C:30]([O-:32])=[O:31])=[CH:40][CH:41]=2)=[CH:42][CH:43]=1)[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1.[Na+:2]