Methanol → HCID 22388536, compound

HRID 1072835Notes

Reaction equation

HRID 1072835 reaction equation
[C:1]([C:4]1[C:9]2[S:10][CH:11]=[C:12]([CH2:13][CH3:14])[C:8]=2[CH:7]=[CH:6][CH:5]=1)([OH:3])=[O:2].S(=O)(=O)(O)O.[CH3:20]O>>[CH2:13]([C:12]1[C:8]2[CH:7]=[CH:6][CH:5]=[C:4]([C:1]([O:3][CH3:20])=[O:2])[C:9]=2[S:10][CH:11]=1)[CH3:14]

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 22388390HCID 22388390, compound

Product 1

HCID 22388536HCID 22388536, compound

Procedure

7-Carboxy-3-ethylbenzo[b]thiophene (3.20 g) and concentrated sulfuric acid were stirred in methanol (100 ml) at 60° C. for 16 hr. The reaction mixture was concentrated and chloroform was added thereto. The mixture was washed with a saturated aqueous solution of sodium hydrogencarbonate. The chloroform was separated, and the residue was dried over magnesium sulfate, and concentrated to give the objective compound (3.04 g).

Workup

  1. concentrationThe reaction mixture was concentrated
  2. additionchloroform was added
  3. washThe mixture was washed with a saturated aqueous solution of sodium hydrogencarbonate
  4. customThe chloroform was separated
  5. dry with materialthe residue was dried over magnesium sulfate
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-470823a593df4caabd5cd30bcc063b37
Source dataset
uspto-grants-2005_06
Patent number
US06911469B2

Reaction notes

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