反应详情

温度

4.5 °C

4-Ethylbenzoic acid (20 g, 133 mmol) was ice-cooled and fuming nitric acid (94%, d=1.50, 50 ml) was dropwise added thereto for 40 min. The mixture was stirred at 4-5° C. for 1.25 hr. The resulting yellow suspension was poured into ice-water and the precipitated crystals were collected by filtration. The crystals were dissolved in ethanol, and water was added for recrystallization to give the objective compound (24.6 g, 94.8%) as colorless crystals.

1. temperaturecooled
2. filtrationthe precipitated crystals were collected by filtration
3. dissolutionThe crystals were dissolved in ethanol
4. additionwater was added for recrystallization