2,4-Dichlorobenzylamine → HCID 22388178, compound

Participants

Reaction Steps

A mixture of dimethyl 2-aminoterephthalate (4.18 g), N,N′-carbonyldiimidazole (3.89 g) and N-methylmorpholine (4.0 ml) in tetrahydrofuran (30 ml) was stirred at room temperature for 21 hr. After concentration of the reaction mixture, acetonitrile (70 ml) and 2,4-dichlorobenzylamine (5.47 g) were added and the mixture was stirred at reflux temperature for 2 hr. The precipitated solid was washed with water (50 ml) and acetonitrile (50 ml) and dried to give the objective compound (4.64 g).

Provenance & Evidence