Sulfuric Acid → HCID 22388023, compound

HRID 1072857Notes

Reaction equation

HRID 1072857 reaction equation
[Cl:1][C:2]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:3]=1[CH2:4][C:5]1[N:14]([CH3:15])[C:13](=[O:16])[C:12]2[C:7](=[CH:8][C:9]([C:17](=[O:20])NC)=[CH:10][CH:11]=2)[N:6]=1.S(=O)(=O)(O)[OH:27]>O>[C:17]([C:9]1[CH:8]=[C:7]2[C:12]([C:13](=[O:16])[N:14]([CH3:15])[C:5]([CH2:4][C:3]3[CH:21]=[CH:22][C:23]([Cl:25])=[CH:24][C:2]=3[Cl:1])=[N:6]2)=[CH:11][CH:10]=1)([OH:20])=[O:27]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 22388550HCID 22388550, compound

Product 1

HCID 22388023HCID 22388023, compoundYield 81.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
100 °C

Procedure

2-(2,4-Dichlorobenzyl)-3-methyl-7-(methylcarbamoyl)-4(3H)-quinazolinone (0.88 g) in a mixture of concentrated sulfuric acid (2.0 g) and water (2.0 g) was stirred at 100° C. for 7 hr. After cooling of the reaction mixture, water (5 ml) was added. The precipitate was collected by filtration, washed with methanol and dried to give the objective compound (0.69 g) as white crystals.

Workup

  1. additionwas added
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with methanol
  4. customdried

Sources & evidence

ORD record
ord-4076bc0ec8bd46808a5d0f17b66b5800
Source dataset
uspto-grants-2005_06
Patent number
US06911469B2

Reaction notes

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