Sulfuric Acid → HCID 22387822, compound

HRID 1072863Notes

Reaction equation

HRID 1072863 reaction equation
[C:1]([C:4]1[CH:13]=[C:12]2[C:7]([C:8](=[O:24])[N:9]=[C:10]([CH3:23])[N:11]2[CH2:14][C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=2[Cl:22])=[CH:6][CH:5]=1)(=[O:3])N.S(=O)(=O)(O)[OH:26]>O>[C:1]([C:4]1[CH:13]=[C:12]2[C:7]([C:8](=[O:24])[N:9]=[C:10]([CH3:23])[N:11]2[CH2:14][C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=2[Cl:22])=[CH:6][CH:5]=1)([OH:3])=[O:26]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 22388387HCID 22388387, compound

Product 1

HCID 22387822HCID 22387822, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

7-Carbamoyl-1-(2,4-dichlorobenzyl)-2-methyl-4(1H)-quinazolinone (1.40 g) in a mixture of concentrated sulfuric acid (6 ml) and water (6 ml) was heated at 100° C. for 1 hr. After cooling, the precipitated solid was collected by filtration, washed with water, dried and concentrated to give the object compound (1.46 g) as white crystals.

Workup

  1. temperatureAfter cooling
  2. filtrationthe precipitated solid was collected by filtration
  3. washwashed with water
  4. customdried
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-0b7329c5e01540ae8fbbd0dfa339f47d
Source dataset
uspto-grants-2005_06
Patent number
US06911469B2

Reaction notes

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