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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1072907Generated: November 1, 2026

Thiazolidinedione → HCID 73885113, compound

https://huagongshe.com/reaction/1072907

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThiazolidinedioneHCID 5437—
ReactantPiperidineHCID 8082—
ReactantHCID 22388400HCID 22388400—
SolventEthanolHCID 702—
ProductHCID 73885113HCID 7388511373.3%

Reaction Steps

A suspension of methyl 3-(2-chloro-4-formylbenzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylate (200 mg, 0.582 mmol), thiazolidine-2,4-dione (82 mg, 0.698 mmol) and piperidine (25 mg, 0.291 mmol) in ethanol (4 ml) was refluxed under heating overnight. The reaction mixture was cooled, and the precipitated crystals were filtrated to give the objective compound (189 mg) as pale-yellow crystals.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06911469B2
Source datasetuspto-grants-2005_06
ORD IDord-73ff4809face4256831c96616caa7b2f
Source noteuspto-grants-2005_06