Water → 6-Bromo-3-nitro-2-pyridinamine

HRID 1072912Notes

Reaction equation

HRID 1072912 reaction equation
Br[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Br:11])[N:3]=1.[NH3:12].C(O)C.O>C(O)C>[NH2:12][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Br:11])[N:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 5550532,6-Dibromo-3-nitropyridineHCID 22020343Ethanol, reaction products with ammonia, distn. residues

Product 1

HCID 120977456-Bromo-3-nitro-2-pyridinamine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a suspension of 2,6-dibromo-3-nitropyridine (5.00 g) in ethanol (10 ml) was added an ammonia/ethanol solution (6.8 M, 15 ml) at room temperature, and the mixture was placed in a closed reaction vessel and stirred at room temperature for 19 hr. To the reaction mixture was added water (25 ml), and the precipitate was collected by filtration. The precipitate was washed with ethanol, suspended in ethanol (55 ml), heated and cooled. The precipitate was collected by filtration to give the objective compound (3.19 g) as a yellow powder.

Workup

  1. customthe mixture was placed in a closed reaction vessel
  2. filtrationthe precipitate was collected by filtration
  3. washThe precipitate was washed with ethanol
  4. temperatureheated
  5. temperaturecooled
  6. filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record
ord-ce7b1a9e7b1f4f2498cc96818a00a82d
Source dataset
uspto-grants-2005_06
Patent number
US06911469B2

Reaction notes

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