反应详情

To a solution of 3-chloro-4-methylphenol (500 mg) in ether (5.0 ml) were added acetic anhydride (430 mg) and pyridine (416 mg), and the mixture was stirred at room temperature for 2 hr. The reaction mixture was washed with 1N hydrochloric acid (once) and saturated brine (twice), dried over magnesium sulfate and concentrated to dryness under reduced pressure to give the objective compound (645 mg) as a pale-yellow oil.

1. washThe reaction mixture was washed with 1N hydrochloric acid (once) and saturated brine (twice),
2. dry with materialdried over magnesium sulfate
3. concentrationconcentrated to dryness under reduced pressure