Benzoyl chloride → HCID 9834203, compound

Temperature

0 °C

To a solution of 1,4-butanediol (18 ml, 0.2 mmol) in pyridine (16 ml), was added slowly at 0° C., under a nitrogen atmosphere, benzoyl chloride (1 ml), 0.1 mmol). After 4 h under stirring at 0° C., the reaction medium was concentrated and the pyridine was eliminated by co-distillation with toluene. The residue was extracted with ether (3×20 ml) and the organic phase was dried (magnesium sulfate), concentrated, and subjected to a flash column chromatography on silica gel (petroleum ether/ethyl acetate 3:2) to give the 4-hydroxybutyl benzoate (9.9 g, 55%) in the form of a colorless oil.

1. concentrationthe reaction medium was concentrated
2. extractionThe residue was extracted with ether (3×20 ml)
3. dry with materialthe organic phase was dried (magnesium sulfate)
4. concentrationconcentrated

ORD record

ord-cf1a1dad707b4d1b8bd62a72a9afd889

Source dataset

uspto-grants-2005_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06911450B1