Sodium Hydroxide → HCID 22386610, compound

Participants

Reaction Conditions

Reaction Steps

1-(4-benzoyloxybutyloxymethyl)-6-(3,5-dimethylbenzyl)-5-ethyluracil (500 mg, 1.08 mmol) was added to a solution of sodium hydroxide (360 mg, 9 mmol) in methanol (50 ml) and the mixture was stirred at 20° C. for 3 h. After neutralization (concentrated hydrochloric acid) and concentration, the residue was subjected to a flash column chromatography (dichloromethane/methanol 19:1) which gave the 6-(3,5-dimethyl benzyl)-5-ethyl-1-(4-hydroxybutyloxymethyl)uracil (190 mg, 48%) in the form of a white solid.

Provenance & Evidence