Benzoyl chloride → HCID 69748783, compound

HRID 1073017Notes

Reaction equation

HRID 1073017 reaction equation
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:10][CH:11]([CH2:33][O:34][C:35]([C:48]1[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=1)([C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1)[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[CH2:12][NH:13][C:14](=[O:32])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]/[CH:22]=[CH:23]\[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31]>ClCCl.N1C=CC=CC=1>[C:1]([O:10][CH:11]([CH2:33][O:34][C:35]([C:48]1[CH:49]=[CH:50][CH:51]=[CH:52][CH:53]=1)([C:42]1[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=1)[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[CH2:12][NH:13][C:14](=[O:32])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]/[CH:22]=[CH:23]\[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 7412Benzoyl chlorideHCID 69748114HCID 69748114, compound

Product 1

HCID 69748783HCID 69748783, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 21875418Pyridine methylene chlorideSolvent

Procedure

Benzoyl chloride (30 mmol) is added dropwise at 0° C. to a solution of 10 (27.3 mmol) in 80 ml of dichloromethane/pyridine (1:1). Slow warming to room temperature is allowed to take place, and stirring is continued for another 4 hours at room temperature. The mixture is then concentrated, added twice with 50 ml of toluene and concentrated. The residue is added with 100 ml of H2O and extracted three times with 100 ml of dichloromethane. The combined organic phases are washed with 50 ml of cold 5% HCl and 50 ml of saturated NaCl solution, dried over MgSO4, filtrated and concentrated. The residue is purified by silica gel chromatography using heptane/ethyl acetate (3:1). Yield: 87% of a colorless oil.

Workup

  1. concentrationThe mixture is then concentrated
  2. additionadded twice with 50 ml of toluene
  3. concentrationconcentrated
  4. additionThe residue is added with 100 ml of H2O
  5. extractionextracted three times with 100 ml of dichloromethane
  6. washThe combined organic phases are washed with 50 ml of cold 5% HCl and 50 ml of saturated NaCl solution
  7. dry with materialdried over MgSO4
  8. filtrationfiltrated
  9. concentrationconcentrated
  10. customThe residue is purified by silica gel chromatography

Sources & evidence

ORD record
ord-08472dff46634545b1accb43b9651aae
Source dataset
uspto-grants-2005_06
Patent number
US06911553B1

Reaction notes

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