Sodium Hydroxide → HCID 15070277, compound

Participants

Reaction Steps

To 150 ml of an ethanol solution of 5.4 g of 2-(4,6-dimethoxypyrimidin-2yl)oxy-3,3-dimethyl-γ-butyrolactone, 20 ml of an aqueous solution of 1.2 g of sodium hydroxide was added, and then, the mixture was stirred at room temperature for one hour. Ethanol was evaporated under reduced pressure, and the reaction solution was adjusted to pH 2 to 3 with 5% hydrochloric acid. The reaction solution was extracted twice with ethyl acetate, washed twice with a sodium chloride aqueous solution and then dried over anhydrous magnesium sulfate. The desiccating agent was removed by filtration, and then the filtrate was concentrated under reduced pressure to obtain 4.7 g of the desired product.

Provenance & Evidence