反应详情

10.4 g of 2-mercapto-4,6-dimethoxypyrimidine, 15.0 g of ethyl 2-(1-cyclopentenyl)-2-(methylsulfonyloxy)acetate, 100 ml of N,N-dimethylformamide and 9.2 g of anhydrous potassium carbonate were stirred at 90° C. for 5 hours. The reaction mixture was cooled to room temperature and then diluted with water. The aqueous mixture was extracted with ethyl ether. The ethyl ether extract was washed with water and dried. Then, ethyl ether was removed by distillation under reduced pressure to obtain an yellow oily substance. The yellow oily substance was purified by silica gel column chromatography (eluent: hexane/ethyl acetate =10/1) to obtain 9.7 g of the desired product.

1. extractionThe aqueous mixture was extracted with ethyl ether
2. extractionThe ethyl ether extract
3. washwas washed with water
4. customdried
5. customThen, ethyl ether was removed by distillation under reduced pressure
6. customto obtain an yellow oily substance
7. customThe yellow oily substance was purified by silica gel column chromatography (eluent: hexane/ethyl acetate =10/1)