Isopropylamine → HCID 22157818, compound

HRID 1073032Notes

Reaction equation

HRID 1073032 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([S:11][CH:12]([CH:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)[C:13]([OH:15])=[O:14])[N:4]=1.[CH:21]([NH2:24])([CH3:23])[CH3:22]>CO>[CH3:10][O:9][C:7]1[CH:8]=[C:3]([O:2][CH3:1])[N:4]=[C:5]([S:11][CH:12]([CH:16]2[CH2:17][CH2:18][CH2:19][CH2:20]2)[C:13]([O-:15])=[O:14])[N:6]=1.[CH:21]([NH3+:24])([CH3:23])[CH3:22]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 15070295HCID 15070295, compound

Product 1

HCID 22157818HCID 22157818, compoundYield 71.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 5.0 g of 2-(4,6-dimethoxypyrimidin-2-yl)thio-2-cyclopentyl acetic acid, 1.0 g of isopropylamine and 80 ml of methanol was stirred at room temperature for 1.5 hours. Methanol was removed by distillation under reduced pressure. Isopropyl ether was added to the residue, and the mixture was stirred at room temperature for 0.5 hour. Formed crystals were collected by filtration, washed with n-hexane and then dried to obtain 4.3 g of the desired product.

Workup

  1. customMethanol was removed by distillation under reduced pressure
  2. additionIsopropyl ether was added to the residue
  3. stirringthe mixture was stirred at room temperature for 0.5 hour
  4. customFormed crystals
  5. filtrationwere collected by filtration
  6. washwashed with n-hexane
  7. customdried

Sources & evidence

ORD record
ord-3e2d3d448f5b49699887e1bb33fc7ab1
Source dataset
uspto-grants-1990_11
Patent number
US04968340

Reaction notes

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