Acetic Acid → HCID 15070305, compound

HRID 1073034Notes

Reaction equation

HRID 1073034 reaction equation
[CH3:1][C:2]([CH3:26])([CH3:25])[CH:3]([O:14][C:15]1[N:20]=[C:19]([O:21][CH3:22])[N:18]=[C:17]([O:23][CH3:24])[N:16]=1)[C:4]([O:6]CC1C=CC=CC=1)=[O:5].C(O)(=O)C.[H][H]>[C].[Pd].C(O)C>[CH3:1][C:2]([CH3:26])([CH3:25])[CH:3]([O:14][C:15]1[N:16]=[C:17]([O:23][CH3:24])[N:18]=[C:19]([O:21][CH3:22])[N:20]=1)[C:4]([OH:6])=[O:5]

Participants

6

Reactant 3

HCID 176Acetic AcidHCID 15070304HCID 15070304, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 15070305HCID 15070305, compoundYield 91.8%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

4.5 g of benzyl 3,3-dimethyl-2-(4,6-dimethoxy-S-triazin-2-yl)oxybutyrate and 0.5 g (10%) of palladium carbon wetted with 2 ml of acetic acid were added to 100 ml of ethanol. 257 ml of hydrogen was added thereto at room temperature under stirring. The reaction solution was subjected to filtration, and the filtrate was extracted twice with 200 ml of ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain 3.1 g of the desired product.

Workup

  1. filtrationThe reaction solution was subjected to filtration
  2. extractionthe filtrate was extracted twice with 200 ml of ethyl acetate
  3. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-d30e8509108541348cdbe1bae6574731
Source dataset
uspto-grants-1990_11
Patent number
US04968340

Reaction notes

Loading…