HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1073063Generated: October 25, 2026
Pyridine → 7-chloro-l-(2-ethylthio-3-pyridylcarbonyl)-2,3-dihydro-4(lH)-quinolinone
https://huagongshe.com/reaction/1073063
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 7-Chloro-2,3-dihydro-4-quinolone | HCID 88974 | — |
| Reactant | 2-(Ethylthio)Nicotinoyl Chloride | HCID 2774534 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 7-chloro-l-(2-ethylthio-3-pyridylcarbonyl)-2,3-dihydro-4(lH)-quinolinone | HCID 22157978 | — |
Reaction Steps
To a mixture of 7-chloro-2,3-dihydro-4(lH)-quinolinone (25 g), pyridine (32 g) and dioxane (200 ml) was added dropwise 2-ethylthio-3-pyridylcarbonyl chloride (37 under cooling at 0 C. to 5° C. with stirring. The mixture was allowed to react at room temperature for additional 3 hours. The reaction mixture was subjected to the procedure described in example 1, and 43 g of 7-chloro-l-(2-ethylthio-3-pyridylcarbonyl)-2,3-dihydro-4(lH)-quinolinone was obtained as white crystal.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04968680 |
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| Source dataset | uspto-grants-1990_11 |
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| ORD ID | ord-5c5615cdc391407fba391293e48e8d9b |
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| Source note | uspto-grants-1990_11 |
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