Benzoyl isothiocyanate → HCID 53678193, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 5.2 g (32 mmol) of benzoyl isothiocyanate in 20 ml of chloroform is added dropwise at room temperature to a suspension of 8.8 g (29 mmol) of 6-[4-(1-piperazinyl)-3-nitro-phenyl]-4,5-dihydro-3(2H)-pyridazinone in 300 ml of chloroform. The reaction mixture is stirred for 2 hours at 30° C. and cooled in an ice bath and the precipitated solid is separated by suction filtration. 12.5 g (93% of theoretical) of orange coloured crystals melting at 140°-141.5° C. remain after drying.

Provenance & Evidence