Potassium Carbonate → HCID 178429566, compound

Participants

Reaction Conditions

Reaction Steps

3.0 g (9.5 mmol) of 6-[4-(1-Piperazinyl)-3-nitro-phenyl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone and 1.7 g (10.5 mmol) of carbonyl diimidazole are stirred together in 30 ml of DMF at room temperature for 2 hours. 1.88 g (15 mmol) of 3-(1H-imidazol-4-yl)-propylamine are then added and the reaction mixture is heated to 70° C. for 8 hours. After cooling, 10 ml of a saturated aqueous potassium carbonate solution are added and the reaction mixture is extracted with chloroform. The organic phase is concentrated by evaporation under vacuum and the residue is chromatographed on silica gel (Solvent F). Concentration of the main fractions by evaporation and crystallization of the residue yields 2.3 g (52% of theoretical) of orange crystals which have a melting point of 182° C.

Provenance & Evidence