4-Pyridineacetic acid → HCID 86744333, compound

HRID 1073144Notes

Reaction equation

HRID 1073144 reaction equation
[N:1]1[CH:6]=[CH:5][C:4](CC(O)=O)=[CH:3][CH:2]=1.[C:11]([O-:18])(=[O:17])/[CH:12]=[CH:13]/[C:14]([O-:16])=[O:15]>>[C:11]([OH:18])(=[O:17])/[CH:12]=[CH:13]/[C:14]([OH:16])=[O:15].[N:1]1([CH:2]2[CH:2]3[CH:3]([CH2:4][CH2:5][CH2:6][NH:1]3)[CH2:5][CH2:4][CH2:3]2)[CH2:14][CH2:13][CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 342284-Pyridineacetic acidHCID 5460307Fumarate

Product 1

HCID 86744333HCID 86744333, compound

Procedure

Using the procedure of Example 8, 452 mg of 4-pyridyl-acetic acid were reacted with stirring for 3 hours and the product obtained in the form of a base was converted into fumarate by the method of Example 4 to obtain 373 mg of [4aRS(4aα, 8α, 8aα)](±)-1-(4-pyridinyl)-acetyl]-decahydro-8-(1-pyrrolidinyl)-quinoline fumarate melting at 232° C.

Workup

  1. customwere reacted
  2. customthe product obtained in the form of a base

Sources & evidence

ORD record
ord-c773d441c9ec40ef82ab86118173664f
Source dataset
uspto-grants-1990_11
Patent number
US04968700

Reaction notes

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