Ethyl 2-methyl-4-(phenylmethyl)-1-piperazinecarboxylate → Ethyl 2-methyl-1-piperazinecarboxylate

HRID 1073161Notes

Reaction equation

HRID 1073161 reaction equation
[CH3:1][CH:2]1[CH2:7][N:6](CC2C=CC=CC=2)[CH2:5][CH2:4][N:3]1[C:15]([O:17][CH2:18][CH3:19])=[O:16].[H][H]>[Pd].CO>[CH3:1][CH:2]1[CH2:7][NH:6][CH2:5][CH2:4][N:3]1[C:15]([O:17][CH2:18][CH3:19])=[O:16]

Participants

5

Reactant 2

HCID 14722553Ethyl 2-methyl-4-(phenylmethyl)-1-piperazinecarboxylateHCID 178418361HCID 178418361, compound

Product 1

HCID 14722554Ethyl 2-methyl-1-piperazinecarboxylateYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 21 parts of ethyl 2-methyl-4-(phenylmethyl)-1-piperazinecarboxylate and 200 parts of methanol was hydrogenated at normal pressure and at room temperature with 3 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated. The residue was distilled twice, yielding 23 parts (100%) of ethyl 2-methyl-1-piperazinecarboxylate; bp. 95°-98° C. at 66.5 pa (int. 37).

Workup

  1. filtrationthe catalyst was filtered off
  2. customthe filtrate was evaporated
  3. distillationThe residue was distilled twice

Sources & evidence

ORD record
ord-64e90b93613946f29b3e2c55bced8cf3
Source dataset
uspto-grants-1990_11
Patent number
US04968684

Reaction notes

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