HCID 19992418, compound → HCID 19992420, compound

HRID 1073202Notes

Reaction equation

HRID 1073202 reaction equation
[CH3:1][N:2]([C:13]1[CH:18]=[CH:17][C:16]([N+:19]([O-])=O)=[CH:15][CH:14]=1)[CH2:3][CH2:4][N:5]([CH3:12])[C:6]1[CH:11]=[CH:10][N:9]=[CH:8][CH:7]=1>CO>[NH2:19][C:16]1[CH:17]=[CH:18][C:13]([N:2]([CH3:1])[CH2:3][CH2:4][N:5]([CH3:12])[C:6]2[CH:11]=[CH:10][N:9]=[CH:8][CH:7]=2)=[CH:14][CH:15]=1

Participants

3

Reactant 1

HCID 19992418HCID 19992418, compound

Product 1

HCID 19992420HCID 19992420, compoundYield 100.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of the product of part (ii) (0.50 g) in methanol (50 ml) was hydrogenated at room temperature and 3.5 bar in the presence of 5% palladium on carbon (50 mg) until the required amount of hydrogen had been absorbed. The catalyst was filtered off and the filtrate was evaporated to give the title compound (0.45 g) as a gum which was used without further purification.

Workup

  1. customwas hydrogenated at room temperature
  2. custom3.5 bar in the presence of 5% palladium on carbon (50 mg) until the required amount of hydrogen had been absorbed
  3. filtrationThe catalyst was filtered off
  4. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-cda06bc2a8f640d386ef3d6dc67930bf
Source dataset
uspto-grants-1990_11
Patent number
US04968704

Reaction notes

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