2-Amino-1-(3-chlorophenyl)ethan-1-ol → HCID 14279406, compound

HRID 1073205Notes

Reaction equation

HRID 1073205 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]([OH:11])[CH2:9][NH2:10])[CH:5]=[CH:6][CH:7]=1.O=[C:13]([CH3:25])[CH2:14][C:15]1[CH:24]=[CH:23][C:18]([C:19]([O:21][CH3:22])=[O:20])=[CH:17][CH:16]=1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]([OH:11])[CH2:9][N:10]=[C:13]([CH3:25])[CH2:14][C:15]2[CH:24]=[CH:23][C:18]([C:19]([O:21][CH3:22])=[O:20])=[CH:17][CH:16]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 37516012-Amino-1-(3-chlorophenyl)ethan-1-olHCID 11137970Methyl 4-(2-oxopropyl)benzoate

Product 1

HCID 14279406HCID 14279406, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

2-(3-Chlorophenyl)-2-hydroxyethylamine (24.4 g, 0.142 mol) and methyl 4-(2-oxopropyl)benzoate (26 g, 0.135 mol) were combined and refluxed in 500 ml toluene for 3 hours, collecting formed H2O with a Dean-Stark trap. The reaction mixture was cooled and stripped of solvent to yield intermediate methyl 4-[2-(2-(3-chlorophenyl)-2-hydroxyethylimino)propyl]benzoate.

Workup

  1. customcollecting
  2. customformed H2O with a Dean-Stark trap
  3. temperatureThe reaction mixture was cooled

Sources & evidence

ORD record
ord-64d6b8a3e2bc4b1da34484601ab25002
Source dataset
uspto-grants-1990_11
Patent number
US04968707

Reaction notes

Loading…