Dimethylformamide → HCID 86744335, compound

Participants

Reaction Conditions

Reaction Steps

The hydrochloride, 20.7 g, was added to 59.5 g of phosphorus oxychloride and 200 ml of dimethylformamide followed by heating at 60° C. for 3 hours. After completion of the reaction, the reaction solution was poured onto ice water containing sodium carbonate. The precipitated crystals were taken out by filtration and recrystallized from ethanol to give 8.77 g of 7-fluoro-3-formyl-3-methylimidazo[2,1-b]benzothiazole. Subsequently, the resulting formyl compound and 1.00 g of sodium borohydride were refluxed in ethanol for one hour. After completion of the reaction, ethanol was removed and the residue was recrystallized from methanol to give 2.74 g of the title compound.

Provenance & Evidence